Hughes’ syndrome is a disorder that is characterized by blood coagulation. This causes blood clots (thrombosis) in both your arteries and veins. There can also be pregnancy-related complications such as miscarriage, preterm delivery or severe preeclampsia.
The syndrome occurs due to the autoimmune production of antibodies against phospholipid (aPL), which is a cell membrane substance. In particular, the disease is characterized by antibodies that are formed against cardiolipin (anti-cardiolipin antibodies) and β2 glycoprotein I.
Primary Hughes’ syndrome refers to this disorder when it occurs in the absence of any other related disease. It is referred to as secondary Hughes’ syndrome when it happens in conjunction with other autoimmune diseases like lupus. In rare cases, Hughes’ syndrome leads to rapid organ failure that is due to generalized thrombosis. In these cases there is a high risk of death. This is termed “catastrophic Hughes’ syndrome”.
Hughes’ syndrome is named after the rheumatologist Dr. Graham R.V. Hughes who worked at the Louise Coote Lupus Unit at St Thomas’ Hospital in London. In the 1980’s, Dr. Hughes and his colleagues provided additional understanding of this disorder.
Hughes’ syndrome is known by other names. It is also referred to as antiphospholipid syndrome (APS) and antiphospholipid antibody syndrome.
Anywhere from 1 to 5% of the general population is thought to have Hughes’ syndrome. It is a major concern for women as 75 to 90% of those with this disorder are women. 10 to 25% of recurrent miscarriages are due to Hughes’ syndrome. One third of all strokes that happen to people under the age of 50 are caused by this disorder. 15 to 20% of all cases of blood clots in large veins (deep vein thrombosis) are caused by Hughes’ syndrome.
The effects you have with Hughes’ syndrome depend on where blood clots form in your body or where they travel to. A clot that forms or a traveling clot (embolus) may cause these effects:
- Stroke
- Recurring miscarriages or stillbirths and other complications of pregnancy
- Blood clots that travel to you lungs (pulmonary embolism)
- Blood clots in your legs (deep vein thrombosis).
There are other less common effects that you may experience. These include:
- Cardiovascular disease
- Bleeding
- Neurological symptoms like headaches, seizures and dementia
- Rash
- Mental health problems like psychosis or depression
- Movement disorder (chorea)
- Sudden hearing loss
- Cognitive problems like poor memory.
You may have Hughes’ Syndrome. As a result, you may need financial assistance.
Have you applied for Social Security disability benefits or disability benefits from the Social Security Administration because of the disability caused by Hughes’ syndrome? Were you denied?
If you are going to appeal the denial, here is something to remember. People who are represented in this process by a disability attorney like the one you will find at Social Security Home are approved more often that people without a lawyer.



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