Osteoid is your bone protein matrix that is made up primarily of type 1 collagen. When there is insufficient mineral or osteoblast dysfunction, your osteoid accumulates because it does not mineralize properly.
When the newly formed bone of the growth plate does not mineralize, the growth plate becomes wide, irregular and thick. This leads to the clinical diagnosis of rickets. This is true only of children as adults no longer have growth plates. Osteomalacia develops when the remodeled bone does not mineralize. This occurs in all ages. Most of the hereditary causes of osteomalacia appear during childhood and cause rickets.
Osteomalacia is marked by a softening of your bones. In fact, the meaning of osteomalacia is “soft bones”.
Soft bones are more prone to bow and fracture than are harder, healthy bones. Your bone tends to break down faster than it can re-form in the case of osteomalacia.
Osteomalacia is not the same as osteoporosis. Osteoporosis is another bone disorder that can also result in bone fractures. Osteomalacia is caused by a defect in your bone-building process. Osteoporosis is due to a weakening of previously constructed bone.
Axial osteomalacia is a rare form of osteomalacia. It is a disorder that is marked by an enzyme defect that affects bone formation. Axial osteomalacia primarily affects your hip bone (iliac crest) and your ribs.
There is a racial predilection with axial osteomalacia. This disorder occurs predominantly in blacks and Caucasians.
Your body has to have phosphate and calcium in order to build healthy, strong bones. If your body does not absorb these minerals correctly or if you do not get enough of them in your diet, this may result in axial osteomalacia. Some of the things that may cause these difficulties include:
An autoimmune disease that is called celiac disease
Certain drugs that are used to treat seizures like Phenobarbital and phenytoin
Certain surgeries like gastrectomy (removing all or part of your stomach)
Liver or kidney diseases
Vitamin D deficiency.
There are several signs and symptoms that may be an indication of axial osteomalacia. Some of these are:
Impaired bone formation
Fatigue in your extremities
Limited range of motion in your spinal area
Vague chronic axial pain
Tenderness over your lumbar spine
Back pain.
You or a loved one may have axial osteomalacia. Axial osteomalacia and/or complications that have resulted from it or other conditions that you have in addition to this disorder may have caused the disability of you or your loved one and be what is preventing you from being able to work.
Related articles
- Osteomalacia (Adults) or Rickets (Children) – Soft Bone Disease (healthhype.com)
- The Truth About Vtiamin D: Why You Need Vitamin D (webmd.com)
- Angiomatoid Fibrous Histiocytoma and Receiving Social Security Disability (socialsecurityhome.com)


